If given to elderly patients, diphenhydramine can cause confusion and agitation. Because of this, diphenhydramine is not recommended in elderly patients for insomnia or treatment for the common cold; though it should still be given in cases of allergic reaction. The specific treatment provided to patients with diphenhydramine poisoning may vary depending on the symptoms experienced.
Care may include providing hydration with fluids through an intravenous line inserted into a vein, giving calming medications to decrease confusion and agitation or to treat seizures, or placing the patient on a breathing machine with deep sedation until the medication effects wear off.
Some patients may be treated with an antidote called physostigmine, which may reverse some of the effects of diphenhydramine in the brain. If taken with other sleep-aids or pain medications, extreme drowsiness may occur; this is due to the fact that many of these medications have similar uses and side effects. These answers are provided by volunteer medical toxicologists for the purpose of public education, and do not necessarily represent the policies or positions of the American College of Medical Toxicology.
All data and information provided in this FAQ is for informational purposes only. ACMT makes no representations as to accuracy, completeness, currentness, suitability, or validity of the content of the FAQ and will not be liable for any errors or omissions in this information or any losses, injuries, or damages arising from its display or use. You can call for any reason, 24 hours a day, 7 days a week. The health care provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure.
Recovery is likely if the person survives the first 24 hours. Complications such as pneumonia, muscle damage from lying on a hard surface for a long period of time, or brain damage from lack of oxygen may result in permanent disability.
Few people actually die from an antihistamine overdose. However, serious heart rhythm disturbances may occur, which can cause death. Aronson JK. Anticholinergic drugs. In: Aronson JK, ed. Meyler's Side Effects of Drugs. Waltham, MA: Elsevier; Philadelphia, PA: Elsevier; chap Editorial team. Next Chapter. Manning B Manning, Beth. Chapter In: Olson KR. Olson K. Kent R. McGraw Hill; Accessed November 12, Olson KR. McGraw Hill. Download citation file: RIS Zotero. Reference Manager.
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